Recombinant Human 39S ribosomal protein L39, mitochondrial (MRPL39)

Uniprot Id

Q9NYK5

Target Species

Human

Target Name

MRPL39

Target Full Name

Large ribosomal subunit protein mL39

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mL39 family

Target Tissue Specificity

Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific.

Target Synonyms

MRPL39; C21orf92; MRPL5; RPML5; MSTP003; PRED22; 39S ribosomal protein L39; mitochondrial; L39mt; MRP-L39; 39S ribosomal protein L5; mitochondrial; L5mt; MRP-L5; Mitochondrial large ribosomal subunit protein mL39

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q.