Recombinant Human 39S ribosomal protein L50, mitochondrial (MRPL50)

Uniprot Id

Q8N5N7

Target Species

Human

Target Name

MRPL50

Target Full Name

Large ribosomal subunit protein mL50

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mL50 family

Target Synonyms

MRPL50; 39S ribosomal protein L50; mitochondrial; L50mt; MRP-L50; Mitochondrial large ribosomal subunit protein mL50

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q.