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| Cat.No | ACP21325 | Target Name | PFKFB2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-505 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60825 |
|---|
Uniprot Id
O60825
Target Species
Human
Target Name
PFKFB2
Target Full Name
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Target Function
Synthesis and degradation of fructose 2,6-bisphosphate.
Target Protein Families
Phosphoglycerate mutase family
Target Tissue Specificity
Heart.
Target Synonyms
6 phosphofructo 2 kinase/fructose 2 6 biphosphatase 2 ; 6-bisphosphatase; 6-P2ase 2; 6-P2ASE heart-type isozyme; 6PF 2 K/Fru 2 6 P2ASE heart type isozyme; 6PF-2-K/Fru-2; 6PF-2-K/Fru-26-P2ase 2; 6PF-2-K/Fru-26-P2ase heart-type isozyme; F262_HUMAN; Fructose 2 6 bisphosphatase cardiac isozyme; Fructose-2; PFK 2/FBPase 2; PFK/FBPase 2; PFKFB cardiac ; PFKFB2
Target Background
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate, and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of fructose-2, 6-bisphosphate. This protein regulates fructose-2, 6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2, 6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.
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