Recombinant Human Acidic leucine-rich nuclear phosphoprotein 32 family member E (ANP32E)

Uniprot Id

Q9BTT0

Target Species

Human

Target Name

ANP32E

Target Full Name

Acidic leucine-rich nuclear phosphoprotein 32 family member E

Target Function

Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

ANP32 family

Target Tissue Specificity

Expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver and kidney.

Target Synonyms

Acidic (leucine rich) nuclear phosphoprotein 32 family member E; Acidic leucine-rich nuclear phosphoprotein 32 family member E; AN32E_HUMAN; anp32e; Cerebellar postnatal development protein 1; LANP like protein; LANP-L; LANP-like protein; LANPL; Leucine rich acidic nuclear protein like; MGC5350

Target Background

Enables histone binding activity. Involved in histone exchange. Located in nucleus. Part of Swr1 complex.