Recombinant Human Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1), Truncated

Uniprot Id

Q92604

Target Species

Human

Target Name

LPGAT1

Target Full Name

Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

Target Function

Catalyzes the transfert of an acyl group from an acyl-CoA to a lysophosphatidylglycerol (LPG) leading to biosynthesis of phosphatidylglycerol, a precursor for cardiolipin synthesis. Uses various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor. In vitro can also catalyzes the transfert of an acyl group from an acyl-CoA to a monoacylglycerol leading to diacylglycerol synthesis, a precursor of triacylglycerol and plays a role in hepatic triacylglycerol synthesis and secretion. Prefers the sn-2-monoacylglycerol to rac-1-monoacylglycerol as acyl acceptor.

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

1-acyl-sn-glycerol-3-phosphate acyltransferase family

Target Tissue Specificity

Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon.

Target Synonyms

LPGAT1; FAM34A; KIAA0205; Acyl-CoA:lysophosphatidylglycerol acyltransferase 1; Acyl-CoA:monoacylglycerol acyltransferase LPGAT1