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| Cat.No | ACP09407 | Target Name | LYPLA2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-226aa | Mol Weight | 51.6kD |
| Protein Length | Partial of the full length of 1-231aa | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95372 |
|---|
Uniprot Id
O95372
Target Species
Human
Target Name
LYPLA2
Target Full Name
Acyl-protein thioesterase 2
Target Function
Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6. Has lysophospholipase activity. Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide.
Target Subcellular Location
Cytoplasm.
Target Protein Families
AB hydrolase superfamily, AB hydrolase 2 family
Target Tissue Specificity
Expressed in various breast cancer cell lines.
Target Research Area
Metabolism
Target Synonyms
Acyl protein thioesterase 2; Acyl protein thioesterase; Acyl-protein thioesterase 2; APT 2; APT-2; APT2; DJ886K2.4; EC 3.1.2.- ; LPL I; LPL II; LPL-II; LYPA2_HUMAN; LYPLA 2; Lypla2; Lysophospholipase II; LysoPLA II; OTTHUMP00000002999; OTTHUMP00000044831
Target Background
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.
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