Recombinant Human Adenosine kinase (ADK)

Uniprot Id

P55263

Target Species

Human

Target Name

ADK

Target Full Name

Adenosine kinase

Target Function

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Target Involvement

Hypermethioninemia due to adenosine kinase deficiency (HMAKD)

Target Subcellular Location

[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.

Target Protein Families

Carbohydrate kinase PfkB family

Target Tissue Specificity

Widely expressed. Highest level in placenta, liver, muscle and kidney.

Target Synonyms

2310026J05Rik; 5033405D03Rik; Adenosine 5''-phosphotransferase; Adenosine kinase; adk; ADK_HUMAN; AI255373; AI987814; AK; MGC6593; OTTHUMP00000019864; OTTHUMP00000019865

Target Background

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.