Recombinant Human Adenylate kinase isoenzyme 6 (TAF9)

Uniprot Id

Q9Y3D8

Target Species

Human

Target Name

AK6

Target Full Name

Adenylate kinase isoenzyme 6

Target Function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.

Target Subcellular Location

Nucleus, nucleoplasm. Nucleus, Cajal body. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.

Target Protein Families

Adenylate kinase family, AK6 subfamily

Target Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, chorionic villi and the central nervous system.

Target Synonyms

AD-004; Adenylate kinase isoenzyme 6; Adrenal gland protein AD-004; AK/ATPase; AK6; CGI-137; CIP; Coilin-interacting nuclear ATPase protein; Dual activity adenylate kinase/ATPase; hCINAP; KAD6_HUMAN; TAF9