Recombinant Human ADP-ribosylation factor-like protein 2-binding protein (ARL2BP)

The region for expressing recombinant Human ARL2BP contains amino acids 1-163. The theoretical molecular weight of the ARL2BP protein is 45.8 kDa. The ARL2BP protein was expressed in e.coli. The N-terminal GST tag was fused into the coding gene segment of ARL2BP, making it easier to detect and purify the ARL2BP recombinant protein in the later stages of expression and purification.The human ADP-ribosylation factor-like protein 2-binding protein (ARL2BP) is a protein that interacts with ARL2, an ADP-ribosylation factor-like protein involved in intracellular vesicle trafficking. ARL2BP has been implicated in processes related to cellular organization and vesicle transport. It may play a role in microtubule dynamics and centrosome function. Research on ARL2BP aims to uncover its specific cellular functions, interactions with ARL2, and its potential involvement in cellular processes critical for overall cell function and organization.

ACP02981

Number

Cat.No	ACP02981	Target Name	ARL2BP
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-163aa	Mol Weight	45.8kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02981

Target Name

ARL2BP

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-163aa

Mol Weight

45.8kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y2Y0

Background Information

Uniprot Id

Q9Y2Y0
Target Species

Human
Target Name

ARL2BP
Target Full Name

ADP-ribosylation factor-like protein 2-binding protein
Target Function

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
Target Involvement

Retinitis pigmentosa with or without situs inversus (RPSI)
Target Subcellular Location

Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families

ARL2BP family
Target Tissue Specificity

Expressed in retina pigment epithelial cells (at protein level). Widely expressed.
Target Research Area

Signal Transduction
Target Synonyms

ADP ribosylation factor like 2 binding protein; ADP-ribosylation factor-like protein 2-binding protein; AR2BP_HUMAN; Arf like 2 binding protein BART1; ARF-like 2-binding protein; ARL2 binding protein; Arl2bp; ARL2BP protein; BART; BART1; Binder of ARF2 protein 1; Binder of Arl Two; Binder of Arl2; Retinitis pigmentosa 66 (autosomal recessive); RP66
Target Background

ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity.

Recombinant Human ADP-ribosylation factor-like protein 2-binding protein (ARL2BP)

Specifications

Immunogen Information

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