Recombinant Human AH receptor-interacting protein (AIP)

Uniprot Id

O00170

Target Species

Human

Target Name

AIP

Target Full Name

AH receptor-interacting protein

Target Function

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; Cellular negative regulator of the hepatitis B virus (HBV) X protein.

Target Involvement

Pituitary adenoma 1, multiple types (PITA1); Prolactin-secreting pituitary adenoma (PSPA)

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Target Synonyms

AH receptor interacting protein; AH receptor-interacting protein; AIP; AIP_HUMAN; ARA 9; ARA9; Aryl hydrocarbon receptor interacting protein; Aryl-hydrocarbon receptor-interacting protein; fa03h10; FKBP 16; FKBP 37; FKBP16; FKBP37; HBV X associated protein 2; HBV X associated protein; HBV X-associated protein 2; HBVX associated protein ; Immunophilin homolog ARA 9; Immunophilin homolog ARA9; SMTPHN; XAP 2; XAP-2; XAP2

Target Background

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene.