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Amino acids 117-447 constitute the expression domain of recombinant Human ALPP. The theoretical molecular weight of the ALPP protein is 41.9 kDa. This protein is generated in a e.coli-based system. The N-terminal 10xHis tag was fused into the coding gene segment of ALPP, making it easier to detect and purify the ALPP recombinant protein in the later stages of expression and purification.Alkaline phosphatase, placental type (ALPP) is mainly expressed in the placenta, making it a significant subject of research. One of the most prominent areas of investigation is the biological role of ALPP during the pregnancy process. Researchers focus on understanding the functions of ALPP in placental development, maintaining pregnancy stability, and embryo implantation to gain insights into its regulatory mechanisms in the process of gestation. In addition, ALPP is associated with some pregnancy-related disorders, such as preterm birth and pregnancy-induced hypertension. Scientists are dedicated to exploring the role of ALPP in the pathogenesis of these disorders, providing new perspectives for the prevention and treatment of related diseases in the future.
Amino acids 117-447 constitute the expression domain of recombinant Human ALPP. The theoretical molecular weight of the ALPP protein is 41.9 kDa. This protein is generated in a e.coli-based system. The N-terminal 10xHis tag was fused into the coding gene segment of ALPP, making it easier to detect and purify the ALPP recombinant protein in the later stages of expression and purification.Alkaline phosphatase, placental type (ALPP) is mainly expressed in the placenta, making it a significant subject of research. One of the most prominent areas of investigation is the biological role of ALPP during the pregnancy process. Researchers focus on understanding the functions of ALPP in placental development, maintaining pregnancy stability, and embryo implantation to gain insights into its regulatory mechanisms in the process of gestation. In addition, ALPP is associated with some pregnancy-related disorders, such as preterm birth and pregnancy-induced hypertension. Scientists are dedicated to exploring the role of ALPP in the pathogenesis of these disorders, providing new perspectives for the prevention and treatment of related diseases in the future.
| Cat.No | ACP02040 | Target Name | ALPP |
|---|---|---|---|
| Target Synonyms | ALPP; PLAP; Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 117-447aa |
| Mol Weight | 41.9 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05187 |
|---|
Uniprot Id
P05187
Target Species
Human
Target Name
ALPP
Target Full Name
Alkaline phosphatase, placental type
Target Function
Alkaline phosphatase that can hydrolyze various phosphate compounds.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Target Protein Families
Alkaline phosphatase family
Target Tissue Specificity
Detected in placenta (at protein level).
Target Research Area
Tags & Cell Markers
Target Synonyms
ALPP; PLAP; Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1
Target Background
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells.
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