Recombinant Human Alpha-centractin (ACTR1A)

Uniprot Id

P61163

Target Species

Human

Target Name

ACTR1A

Target Full Name

Alpha-centractin

Target Function

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Target Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex.

Target Protein Families

Actin family, ARP1 subfamily

Target Synonyms

Actin related protein 1; Actin RPV; Actin-RPV; ACTR 1A; Actr1a; ACTZ_HUMAN; Alpha centractin; Alpha-centractin; ARP 1; ARP1 actin related protein 1 homolog A; ARP1 actin related protein 1 homolog A centractin alpha; ARP1; ARP1 yeast homolog A; Centractin alpha; Centractin; Centrosome associated actin homolog; Centrosome-associated actin homolog; CTRN 1; CTRN1; FLJ52695; FLJ52800; FLJ55002

Target Background

This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.