Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3), Truncated

Uniprot Id

Q8NDV1

Target Species

Human

Target Name

ST6GALNAC3

Target Full Name

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

Target Function

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis. Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity.

Target Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Target Protein Families

Glycosyltransferase 29 family

Target Tissue Specificity

Expressed in brain and kidney. Observed in the epithelium of the proximal tubules, marginal expression was also found in the distal tubules and collecting tubules.

Target Synonyms

ST6GALNAC3; SIAT7C; UNQ2787/PRO7177Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; EC 2.4.99.7; GalNAc alpha-2,6-sialyltransferase III; ST6GalNAc III; ST6GalNAcIII; STY; Sialyltransferase 7C; SIAT7-C