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| Cat.No | ACP09075 | Target Name | ST6GALNAC6 |
|---|---|---|---|
| Target Synonyms | 6-sialyltransferase 6; EC 2.4.99.-; GalNAc alpha-2, 6-sialyltransferase VI; ST6GalNAc VI; ST6GalNAcVI; hST6GalNAc VI; Sialyltransferase 7F; SIAT7-F, ST6GALNAC6; SIAT7F; UNQ708/PRO1359; Alpha-N-acetylgalactosaminide alpha-2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q969X2 |
|---|
Uniprot Id
Q969X2
Target Species
Human
Target Name
ST6GALNAC6
Target Full Name
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
Target Function
Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside).
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 29 family
Target Tissue Specificity
Expressed in kidney, in proximal tubule epithelial cells. Expressed in colon cell lines.
Target Synonyms
ST6GALNAC6; SIAT7F; UNQ708/PRO1359; Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; EC 2.4.99.-; GalNAc alpha-2,6-sialyltransferase VI; ST6GalNAc VI; ST6GalNAcVI; hST6GalNAc VI; Sialyltransferase 7F; SIAT7-F
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