Recombinant Human Ankyrin-1 (ANK1), Truncated

Uniprot Id

P16157

Target Species

Human

Target Name

ANK1

Target Full Name

Ankyrin-1

Target Function

Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.; Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.

Target Involvement

Spherocytosis 1 (SPH1)

Target Subcellular Location

[Isoform Er1]: Cytoplasm, cytoskeleton. Note=Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane.; [Isoform Mu17]: Membrane. Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with OBSCN isoform 3/obscurin at the M line in differentiated skeletal muscle cells.; [Isoform Mu18]: Sarcoplasmic reticulum.; [Isoform Mu19]: Sarcoplasmic reticulum.; [Isoform Mu20]: Sarcoplasmic reticulum.

Target Tissue Specificity

Isoform Mu17, isoform Mu18, isoform Mu19 and isoform Mu20 are expressed in skeletal muscle. Isoform Br21 is expressed in brain.

Target Synonyms

ANK; ANK-1; Ank1; ANK1_HUMAN; Ankyrin 1; Ankyrin 1; erythrocytic; Ankyrin R; Ankyrin-1; Ankyrin-R; Erythrocyte ankyrin; SPH1; SPH2