Recombinant Human Ankyrin repeat domain-containing protein 2 (ANKRD2)

Uniprot Id

Q9GZV1

Target Species

Human

Target Name

ANKRD2

Target Full Name

Ankyrin repeat domain-containing protein 2

Target Function

Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.

Target Subcellular Location

Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.

Target Tissue Specificity

Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level).

Target Synonyms

ANKRD2; ARPPAnkyrin repeat domain-containing protein 2; Skeletal muscle ankyrin repeat protein; hArpp

Target Background

This gene encodes a protein that belongs to the muscle ankyrin repeat protein (MARP) family. A similar gene in rodents is a component of a muscle stress response pathway and plays a role in the stretch-response associated with slow muscle function. Alternative splicing results in multiple transcript variants encoding different isoforms.