Recombinant Human Antithrombin-III (SERPINC1)

Uniprot Id

P01008

Target Species

Human

Target Name

SERPINC1

Target Full Name

Antithrombin-III

Target Function

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Target Involvement

Antithrombin III deficiency (AT3D)

Target Subcellular Location

Secreted, extracellular space.

Target Protein Families

Serpin family

Target Tissue Specificity

Found in plasma.

Target Research Area

Cardiovascular

Target Synonyms

Serpin C1

Target Background

The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).