Recombinant Human Apelin (APLN)

Cat.No	ACP18864	Target Name	APLN
Target Synonyms	AGTRL1 ligand; APEL; APEL_HUMAN; Apelin 13; Apelin-13; APJ endogenous ligand; Apln; XNPEP2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	42-77
Protein Length	Cytoplasmic Domain	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP18864

Target Name

APLN

Target Synonyms

AGTRL1 ligand; APEL; APEL_HUMAN; Apelin 13; Apelin-13; APJ endogenous ligand; Apln; XNPEP2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

42-77

Protein Length

Cytoplasmic Domain

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9ULZ1

Background Information

Uniprot Id

Q9ULZ1
Target Species

Human
Target Name

APLN
Target Full Name

Apelin
Target Function

Endogenous ligand for the apelin receptor (APLNR). Drives internalization of the apelin receptor. Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR. Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior.; (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives.
Target Subcellular Location

Secreted. Secreted, extracellular space.
Target Protein Families

Apelin family
Target Tissue Specificity

Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.
Target Synonyms

AGTRL1 ligand; APEL; APEL_HUMAN; Apelin 13; Apelin-13; APJ endogenous ligand; Apln; XNPEP2

Recombinant Human Apelin (APLN)

Specifications

Immunogen Information

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