Recombinant Human Apolipoprotein A-IV (APOA4)

Uniprot Id

P06727

Target Species

Human

Target Name

APOA4

Target Full Name

Apolipoprotein A-IV

Target Function

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Target Subcellular Location

Secreted.

Target Protein Families

Apolipoprotein A1/A4/E family

Target Tissue Specificity

Synthesized primarily in the intestine and secreted in plasma.

Target Research Area

Cancer, Cardiovascular

Target Synonyms

APOA4Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4

Target Background

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.