Recombinant Human Apolipoprotein L1 (APOL1)

Uniprot Id

O14791

Target Species

Human

Target Name

APOL1

Target Full Name

Apolipoprotein L1

Target Function

May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.

Target Involvement

Focal segmental glomerulosclerosis 4 (FSGS4)

Target Subcellular Location

Secreted.

Target Protein Families

Apolipoprotein L family

Target Tissue Specificity

Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen.

Target Synonyms

APO L; Apo-L; ApoL; APOL I; ApoL-I; APOL1; APOL1_HUMAN; APOLI; Apolipoprotein L; Apolipoprotein L I; Apolipoprotein L-I; Apolipoprotein L1; FSGS4

Target Background

This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.