Recombinant Human Aquaporin-10 (AQP10), Truncated

Uniprot Id

Q96PS8

Target Species

Human

Target Name

AQP10

Target Full Name

Aquaporin-10

Target Function

Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol, especially when the cytosolic pH is acidified. Contributes to adipocyte water and glycerol permeability, and may thereby contribute to the utilization of glycerol derived from phospholipid degradation. May contribute to water transport in the intestine (Probable).; Water channel that mediates water transport across cell membranes, but that is not permeable to glycerol.

Target Subcellular Location

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Lipid droplet.

Target Protein Families

MIP/aquaporin (TC 1.A.8) family

Target Tissue Specificity

Detected in epithelial cells on villi in the ileum, and also in stomach, jejunum, colon, rectum, white adipose tissue and placenta (at protein level). Expressed in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of vill

Target Synonyms

AQP10; Aquaporin-10; AQP-10; Aquaglyceroporin-10; Small intestine aquaporin

Target Background

This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea.