Recombinant Human Arylamine N-acetyltransferase 2 (NAT2)

Uniprot Id

P11245

Target Species

Human

Target Name

NAT2

Target Full Name

Arylamine N-acetyltransferase 2

Target Function

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Arylamine N-acetyltransferase family

Target Research Area

Signal Transduction

Target Synonyms

AAC2; ARY2_HUMAN; Arylamide acetylase 2 (N-acetyltransferase 2, isoniazid inactivation); Arylamide acetylase 2; Arylamine N-acetyltransferase 2; HGNC:7646; N-acetyltransferase 2 (arylamine N-acetyltransferase); N-acetyltransferase type 2; NAT-2; NAT2; PNAT; Polymorphic arylamine N-acetyltransferase

Target Background

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2).