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| Cat.No | ACP15888 | Target Name | SAMD1 |
|---|---|---|---|
| Target Synonyms | Atherin; SAM domain containing 1; SAM domain-containing protein 1; SAMD1; SAMD1_HUMAN; Sterile alpha motif domain containing 1; Sterile alpha motif domain-containing protein 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-538 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6SPF0 |
|---|
Uniprot Id
Q6SPF0
Target Species
Human
Target Name
SAMD1
Target Full Name
Sterile alpha motif domain-containing protein 1
Target Function
Unmethylated CpG islands (CGIs)-binding protein which localizes to H3K4me3-decorated CGIs, where it acts as a transcriptional repressor. Tethers L3MBTL3 to chromatin and interacts with the KDM1A histone demethylase complex to modulate H3K4me2 and H3K4me3 levels at CGIs. Plays a role in atherogenesis by binding with LDL on cell surface and promoting LDL oxidation which leads to the formation of foam cell.
Target Subcellular Location
Nucleus. Chromosome. Secreted.
Target Tissue Specificity
Expressed in atherosclerotic lesions, not in normal intima. Expressed in foam cells.
Target Synonyms
Atherin; SAM domain containing 1; SAM domain-containing protein 1; SAMD1; SAMD1_HUMAN; Sterile alpha motif domain containing 1; Sterile alpha motif domain-containing protein 1
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