Recombinant Human ATP-binding cassette sub-family B member 9 (ABCB9), Truncated

Uniprot Id

Q9NP78

Target Species

Human

Target Name

ABCB9

Target Full Name

ABC-type oligopeptide transporter ABCB9

Target Function

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.

Target Subcellular Location

Lysosome membrane; Multi-pass membrane protein.

Target Protein Families

ABC transporter superfamily, ABCB family, MHC peptide exporter (TC 3.A.1.209) subfamily

Target Tissue Specificity

Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages.

Target Synonyms

ABCB9; KIAA1520ATP-binding cassette sub-family B member 9; ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL