Recombinant Human ATP-dependent RNA helicase DDX25 (DDX25)

Uniprot Id

Q9UHL0

Target Species

Human

Target Name

DDX25

Target Full Name

ATP-dependent RNA helicase DDX25

Target Function

ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

DEAD box helicase family

Target Tissue Specificity

Highly expressed in the Leydig and germ cells of the testis and weakly expressed in the pituitary and hypothalamus.

Target Synonyms

DDX25; GRTHATP-dependent RNA helicase DDX25; EC 3.6.4.13; DEAD box protein 25; Gonadotropin-regulated testicular RNA helicase

Target Background

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis.