Recombinant Human ATP synthase F (0) complex subunit B1, mitochondrial (ATP5PB)

Uniprot Id

P24539

Target Species

Human

Target Name

ATP5PB

Target Full Name

ATP synthase F(0) complex subunit B1, mitochondrial

Target Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Target Subcellular Location

Mitochondrion. Mitochondrion inner membrane.

Target Protein Families

Eukaryotic ATPase B chain family

Target Research Area

Others

Target Synonyms

AT5F1_HUMAN; ATP synthase B chain mitochondrial; ATP synthase subunit b; ATP synthase subunit b mitochondrial; ATP synthase; H+ transporting; mitochondrial F0 complex; subunit b,; ATP synthase; H+ transporting; mitochondrial F0 complex; subunit b; isoform 1; ATP synthase; H+ transporting; mitochondrial F0 complex; subunit B1; ATP5F1; ATPase subunit b; Cell proliferation inducing protein 47; H+ ATP synthase subunit b; MGC24431; mitochondrial; PIG47

Target Background

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel.