Recombinant Human B-cell antigen receptor complex-associated protein beta chain (CD79B), Truncated

Uniprot Id

P40259

Target Species

Human

Target Name

CD79B

Target Full Name

B-cell antigen receptor complex-associated protein beta chain

Target Function

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Target Involvement

Agammaglobulinemia 6, autosomal recessive (AGM6)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Tissue Specificity

B-cells.

Target Synonyms

CD79B; B29; IGB; B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD antigen CD79b

Target Background

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.