Recombinant Human Bactericidal permeability-increasing protein (BPI)

Uniprot Id

P17213

Target Species

Human

Target Name

BPI

Target Full Name

Bactericidal permeability-increasing protein

Target Function

The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.

Target Subcellular Location

Secreted. Cytoplasmic granule membrane.

Target Protein Families

BPI/LBP/Plunc superfamily, BPI/LBP family

Target Tissue Specificity

Restricted to cells of the myeloid series.

Target Research Area

Immunology

Target Synonyms

Bactericidal permeability-increasing protein; Bactericidal/permeability increasing protein; BPI; BPI fold containing family D; member 1; BPI_HUMAN; BPIFD1; CAP 57; CAP57; rBPI; Recombinant BPI holoprotein; rBPI

Target Background

This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms.