Recombinant Human Bcl-2-modifying factor (BMF)

Uniprot Id

Q96LC9

Target Species

Human

Target Name

BMF

Target Full Name

Bcl-2-modifying factor

Target Function

May play a role in apoptosis. Isoform 1 seems to be the main initiator.

Target Protein Families

Bcl-2 family

Target Tissue Specificity

Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells.

Target Research Area

Cell Biology

Target Synonyms

Bcl 2 modifying factor; Bcl-2-modifying factor; Bcl2 modifying factor; Bmf; BMF_HUMAN; FLJ00065

Target Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.