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Just like other recombinant proteins, the production of this recombinant Human BNIP3L protein began with appropriate cDNA and PCR methods, and then the BNIP3L expression plasmids were built. Following sequence determination of the constructs, plasmids were transformed into Yeast for the expression of the recombinant Human BNIP3L protein. N-terminal 6xHis tag was used in the process. And we finally get the protein of interest with purity of 90%+.BNIP3L (also called BNIP3A, BNIP3H, NIX) is a gene encoding a protein called BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (also known as adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, NIP3-like protein X, NIP3L) in human. The protein encoded by BNP3L gene is a mitochondrial protein from the outer membrane and belongs to the BH3-only protein from the BCL2 family. BNIP3L was initially recognized as a proapoptotic protein with milder efficacy in inducing apoptosis compared to other proteins in this family.
Just like other recombinant proteins, the production of this recombinant Human BNIP3L protein began with appropriate cDNA and PCR methods, and then the BNIP3L expression plasmids were built. Following sequence determination of the constructs, plasmids were transformed into Yeast for the expression of the recombinant Human BNIP3L protein. N-terminal 6xHis tag was used in the process. And we finally get the protein of interest with purity of 90%+.BNIP3L (also called BNIP3A, BNIP3H, NIX) is a gene encoding a protein called BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (also known as adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, NIP3-like protein X, NIP3L) in human. The protein encoded by BNP3L gene is a mitochondrial protein from the outer membrane and belongs to the BH3-only protein from the BCL2 family. BNIP3L was initially recognized as a proapoptotic protein with milder efficacy in inducing apoptosis compared to other proteins in this family.
| Cat.No | ACP04684 | Target Name | BNIP3L |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 1-219aa | Mol Weight | 25.9kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60238 |
|---|
Uniprot Id
O60238
Target Species
Human
Target Name
BNIP3L
Target Full Name
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Target Function
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Target Subcellular Location
Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane; Single-pass membrane protein. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.
Target Protein Families
NIP3 family
Target Research Area
Cancer
Target Synonyms
Adenovirus E1B19k binding protein B5; Adenovirus E1B19K-binding protein B5; BCL2/adenovirus E1B 19 kd protein interacting protein 3a; BCL2/adenovirus E1B 19 kDa protein interacting protein 3A; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A; BCL2/adenovirus E1B 19kDa interacting protein 3 like; BNI3L_HUMAN; BNIP3a; BNIP3H; BNIP3L; BNIP3L protein; NIP3 like protein X; NIP3-like protein X; NIP3L; NIX
Target Background
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c.
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