Recombinant Human Beta-centractin (ACTR1B)

Uniprot Id

P42025

Target Species

Human

Target Name

ACTR1B

Target Full Name

Beta-centractin

Target Function

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Target Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Target Protein Families

Actin family, ARP1 subfamily

Target Synonyms

Actin related protein 1B; Actin-related protein 1B; ACTR 1B; ACTR1B; ACTY_HUMAN; ARP 1B; ARP1 actin related protein 1 homolog B; ARP1 actin related protein 1 homolog B centractin beta (yeast); ARP1 actin related protein 1 homolog B centractin beta; ARP1 actin related protein 1 yeast homolog B centractin beta; ARP1 yeast homolog B; ARP1B; Beta centractin; Beta-centractin; Centractin beta (Yeast); Centractin beta; CTRN 2; CTRN2; PC 3; PC3

Target Background

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex.