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| Cat.No | ACP17708 | Target Name | SNCB |
|---|---|---|---|
| Target Synonyms | 14 kDa brain-specific protein; Beta-synuclein; Phosphoneuroprotein 14; PNP14; Sncb; Synuclein beta; SYUB_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-134 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16143 |
|---|
Uniprot Id
Q16143
Target Species
Human
Target Name
SNCB
Target Full Name
Beta-synuclein
Target Function
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Synuclein family
Target Tissue Specificity
Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
Target Synonyms
14 kDa brain-specific protein; Beta-synuclein; Phosphoneuroprotein 14; PNP14; Sncb; Synuclein beta; SYUB_HUMAN
Target Background
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants.
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