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Enhance your immunological research with our high-quality Recombinant Human PRG2 protein, a crucial component of the bone marrow microenvironment. Bone marrow proteoglycan, also known as BMPG or Proteoglycan 2, plays a significant role in regulating cellular adhesion and growth in the bone marrow niche. Its involvement in these processes makes it an important target for researchers investigating the complex mechanisms underlying immune cell development and homeostasis. Our Recombinant Human PRG2 protein is expressed in E. coli, ensuring a robust and reliable product for your research needs. Covering a partial region of the protein from 17-104aa, our recombinant PRG2 retains key functional domains essential for your experiments. To streamline protein purification and detection, the N-terminal 6xHis-GST tag has been added to our recombinant protein. With a purity greater than 85% as determined by SDS-PAGE, our Recombinant Human PRG2 protein is provided as a lyophilized powder, offering you a consistent and trustworthy tool for your immunology research projects.
Enhance your immunological research with our high-quality Recombinant Human PRG2 protein, a crucial component of the bone marrow microenvironment. Bone marrow proteoglycan, also known as BMPG or Proteoglycan 2, plays a significant role in regulating cellular adhesion and growth in the bone marrow niche. Its involvement in these processes makes it an important target for researchers investigating the complex mechanisms underlying immune cell development and homeostasis.
Our Recombinant Human PRG2 protein is expressed in E. coli, ensuring a robust and reliable product for your research needs. Covering a partial region of the protein from 17-104aa, our recombinant PRG2 retains key functional domains essential for your experiments. To streamline protein purification and detection, the N-terminal 6xHis-GST tag has been added to our recombinant protein. With a purity greater than 85% as determined by SDS-PAGE, our Recombinant Human PRG2 protein is provided as a lyophilized powder, offering you a consistent and trustworthy tool for your immunology research projects.
| Cat.No | ACP01944 | Target Name | PRG2 |
|---|---|---|---|
| Target Synonyms | PRG2; MBP; Bone marrow proteoglycan; BMPG; Proteoglycan 2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 17-104aa |
| Mol Weight | 41.2 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P13727 |
|---|
Uniprot Id
P13727
Target Species
Human
Target Name
PRG2
Target Full Name
Bone marrow proteoglycan
Target Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
Target Subcellular Location
[Bone marrow proteoglycan]: Secreted. Note=The proform is secreted.; [Eosinophil granule major basic protein]: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
Target Tissue Specificity
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and co
Target Research Area
Immunology
Target Synonyms
PRG2; MBP; Bone marrow proteoglycan; BMPG; Proteoglycan 2
Target Background
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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