Recombinant Human Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1), Truncated

Uniprot Id

Q9Y6D6

Target Species

Human

Target Name

ARFGEF1

Target Full Name

Brefeldin A-inhibited guanine nucleotide-exchange protein 1

Target Function

Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined

Target Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Nucleus. Nucleus, nucleolus. Nucleus matrix. Note=Translocates from cytoplasm to membranes and nucleus upon cAMP treatment.

Target Tissue Specificity

Expressed in placenta, lung, heart, brain, kidney and pancreas.

Target Synonyms

ARFGEF1; ARFGEP1; BIG1Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Brefeldin A-inhibited GEP 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1; p200 ARF guanine nucleotide exchange factor; p200 ARF-GEP1

Target Background

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition.