Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
Amino acids 408-534 constitute the expression domain of recombinant Human SPAG9. The expected molecular weight for the SPAG9 protein is calculated to be 20.0 kDa. The SPAG9 protein was expressed in e.coli. The SPAG9 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant SPAG9 protein in following stages of expression and purification.C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) is known to interact with c-Jun N-terminal kinase (JNK), a key component of the mitogen-activated protein kinase (MAPK) signaling pathway. This interaction suggests a role for SPAG9 in mediating cellular responses to extracellular signals, including those related to cell growth, differentiation, and apoptosis. Additionally, SPAG9 has been implicated in the regulation of microtubule dynamics, contributing to cell migration and invasion. Its overexpression has been observed in certain cancers, suggesting a potential role in tumorigenesis.
Amino acids 408-534 constitute the expression domain of recombinant Human SPAG9. The expected molecular weight for the SPAG9 protein is calculated to be 20.0 kDa. The SPAG9 protein was expressed in e.coli. The SPAG9 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant SPAG9 protein in following stages of expression and purification.C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) is known to interact with c-Jun N-terminal kinase (JNK), a key component of the mitogen-activated protein kinase (MAPK) signaling pathway. This interaction suggests a role for SPAG9 in mediating cellular responses to extracellular signals, including those related to cell growth, differentiation, and apoptosis. Additionally, SPAG9 has been implicated in the regulation of microtubule dynamics, contributing to cell migration and invasion. Its overexpression has been observed in certain cancers, suggesting a potential role in tumorigenesis.
| Cat.No | ACP00889 | Target Name | SPAG9 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 408-534aa | Mol Weight | 20.0 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O60271 |
|---|
Uniprot Id
O60271
Target Species
Human
Target Name
SPAG9
Target Full Name
C-Jun-amino-terminal kinase-interacting protein 4
Target Function
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking.
Target Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Lysosome membrane.; [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome.
Target Protein Families
JIP scaffold family
Target Tissue Specificity
Expressed only in testis on the round spermatids of stage I, II and II. Absent in spermatogonia and spermatocyte.; [Isoform 4]: Expressed in testis and in acute myeloid leukemia (AML) patients.; [Isoform 3]: Expressed in testis.
Target Research Area
Developmental Biology
Target Synonyms
SPAG9; HSS; KIAA0516; MAPK8IP4; SYD1; HLC6C-Jun-amino-terminal kinase-interacting protein 4; JIP-4; JNK-interacting protein 4; Cancer/testis antigen 89; CT89; Human lung cancer oncogene 6 protein; HLC-6; JNK-associated leucine-zipper protein; JLP; Mitogen-activated protein kinase 8-interacting protein 4; Proliferation-inducing protein 6; Protein highly expressed in testis; PHET; Sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; Sunday driver 1
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
