Recombinant Human C2 domain-containing protein 2-like (C2CD2L), Truncated

Uniprot Id

O14523

Target Species

Human

Target Name

C2CD2L

Target Full Name

Phospholipid transfer protein C2CD2L

Target Function

Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling. Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers. In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane. Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Peripheral membrane protein.

Target Synonyms

C2CD2L; KIAA0285; TMEM24; DLNB23; Phospholipid transfer protein C2CD2L; C2 domain-containing protein 2-like; C2CD2-like; Transmembrane protein 24