Recombinant Human C5a anaphylatoxin chemotactic receptor 2 (C5AR2), Truncated

Uniprot Id

Q9P296

Target Species

Human

Target Name

C5AR2

Target Full Name

C5a anaphylatoxin chemotactic receptor 2

Target Function

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

Frontal cortex, hippocampus, hypothalamus, pons and liver.

Target Synonyms

C5AR2; C5L2; GPR77; C5a anaphylatoxin chemotactic receptor 2; Complement component 5a receptor 2; G-protein coupled receptor 77

Target Background

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants.