Recombinant Human Calcium-activated chloride channel regulator 2 (CLCA2), Truncated

Uniprot Id

Q9UQC9

Target Species

Human

Target Name

CLCA2

Target Full Name

Calcium-activated chloride channel regulator 2

Target Function

Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.

Target Protein Families

CLCR family

Target Tissue Specificity

Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenita

Target Synonyms

CLCA2; CACC3Calcium-activated chloride channel regulator 2; EC 3.4.-.-; Calcium-activated chloride channel family member 2; hCLCA2; Calcium-activated chloride channel protein 3; CaCC-3; hCaCC-3) [Cleaved into: Calcium-activated chloride channel regulator 2; 109 kDa form; Calcium-activated chloride channel regulator 2; 35 kDa form]