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| Cat.No | ACP06002 | Target Name | KCNMB4 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86W47 |
|---|
Uniprot Id
Q86W47
Target Species
Human
Target Name
KCNMB4
Target Full Name
Calcium-activated potassium channel subunit beta-4
Target Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
KCNMB (TC 8.A.14.1) family, KCNMB4 subfamily
Target Tissue Specificity
Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thala
Target Synonyms
BK channel subunit beta 4; BK channel subunit beta-4; BKbeta4; Calcium activated potassium channel beta 4 subunit; Calcium activated potassium channel subfamily M subunit beta 4; Calcium activated potassium channel subunit beta 4; Calcium-activated potassium channel; Calcium-activated potassium channel subunit beta-4; Charybdotoxin receptor subunit beta 4; Charybdotoxin receptor subunit beta-4; Hbeta4; K(VCA)beta 4; K(VCA)beta-4; KCMB4_HUMAN; KCNMB 4; Kcnmb4; Large conductance calcium dependent potassium ion channel beta 4 subunit; Maxi K channel subunit beta 4; Maxi K channel subunit beta-4; Potassium large conductance calcium activated channel subfamily M beta member 4; Slo beta 4; Slo-beta-4; subfamily M subunit beta-4
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