Recombinant Human Calcium-transporting ATPase type 2C member 2 (ATP2C2), Truncated

Uniprot Id

O75185

Target Species

Human

Target Name

ATP2C2

Target Full Name

Calcium-transporting ATPase type 2C member 2

Target Function

ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Induces Ca(2+) influx independently of its ATP-driven pump function. At the basolateral membrane of mammary epithelial cells, interacts with Ca(2+) channel ORAI1 and mediates Ca(2+) entry independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May facilitate transepithelial transport of large quantities of Ca(2+) for milk secretion via activation of Ca(2+) influx channels at the plasma membrane and active Ca(2+) transport at the Golgi apparatus.

Target Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIA subfamily

Target Tissue Specificity

Highly expressed in the gastrointestinal and respiratory tracts, prostate, thyroid, salivary, and mammary glands. Expressed in colon epithelial cells (at protein level). Expressed in brain and testis (at protein level).

Target Synonyms

AT2C2_HUMAN; ATP2C2; ATPase 2C2; ATPase; Ca++ transporting; type 2C; member 2; Calcium-transporting ATPase type 2C member 2; DKFZp686H22230; hSPCA2; KIAA0703; PMR1; Secretory pathway Ca(2+)-ATPase 2; secretory pathway calcium ATPase 2