Recombinant Human Calcium uptake protein 1, mitochondrial (MICU1), Truncated

Cat.No	ACP05808	Target Name	MICU1
Target Synonyms	mitochondrial ; Calcium-binding atopy-related autoantigen 1; CBARA1; EFHA3; FLJ12684; MICU1; MICU1_HUMAN; mitochondrial; mitochondrial calcium uptake 1 ; MPXPS	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05808

Target Name

MICU1

Target Synonyms

mitochondrial ; Calcium-binding atopy-related autoantigen 1; CBARA1; EFHA3; FLJ12684; MICU1; MICU1_HUMAN; mitochondrial; mitochondrial calcium uptake 1 ; MPXPS

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9BPX6

Background Information

Uniprot Id

Q9BPX6
Target Species

Human
Target Name

MICU1
Target Full Name

Calcium uptake protein 1, mitochondrial
Target Function

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
Target Involvement

Myopathy with extrapyramidal signs (MPXPS)
Target Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space.
Target Protein Families

MICU1 family, MICU1 subfamily
Target Tissue Specificity

Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
Target Synonyms

Allergen Hom s 4; ara CALC; atopy related autoantigen ; atopy related autoantigen CALC ; Atopy-related autoantigen CALC; CALC; calcium binding atopy related autoantigen 1; Calcium uptake protein 1; calcium uptake protein 1, mitochondrial ; Calcium-binding atopy-related autoantigen 1; CBARA1; EFHA3; FLJ12684; MICU1; MICU1_HUMAN; mitochondrial; mitochondrial calcium uptake 1 ; MPXPS
Target Background

This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.

Recombinant Human Calcium uptake protein 1, mitochondrial (MICU1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Calcium uptake protein 1, mitochondrial (MICU1), Truncated Now

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