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The region for expressing recombinant Human CALR contains amino acids 18-417. This CALR protein is expected to have a theoretical molecular weight of 50.6 kDa. Expression of this CALR protein is conducted in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of CALR, making it easier to detect and purify the CALR recombinant protein in the later stages of expression and purification.Calreticulin (CALR) is a multifunctional protein with primary research areas encompassing cell biology and immunology. In cell biology, CALR plays a crucial role in the endoplasmic reticulum, participating in protein folding and modification, and playing a key role in the regulation of intracellular calcium ions. One of the most prominent research directions is the function of CALR in the immune system. CALR plays a critical role in cellular apoptosis, contributing to the immune system's self-recognition and clearance of aberrant cells. Mutations in CALR, particularly in diseases like leukemia, are closely associated with abnormal activation of the immune system, making it a hotspot in immunotherapy and cancer research. In the cardiovascular system, the interaction between CALR and cardiac muscle cells may be related to cardiac pathophysiology. In the nervous system, CALR is associated with neuronal survival and synapse formation, providing insights into research on neurodegenerative diseases.
The region for expressing recombinant Human CALR contains amino acids 18-417. This CALR protein is expected to have a theoretical molecular weight of 50.6 kDa. Expression of this CALR protein is conducted in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of CALR, making it easier to detect and purify the CALR recombinant protein in the later stages of expression and purification.Calreticulin (CALR) is a multifunctional protein with primary research areas encompassing cell biology and immunology. In cell biology, CALR plays a crucial role in the endoplasmic reticulum, participating in protein folding and modification, and playing a key role in the regulation of intracellular calcium ions. One of the most prominent research directions is the function of CALR in the immune system. CALR plays a critical role in cellular apoptosis, contributing to the immune system’s self-recognition and clearance of aberrant cells. Mutations in CALR, particularly in diseases like leukemia, are closely associated with abnormal activation of the immune system, making it a hotspot in immunotherapy and cancer research. In the cardiovascular system, the interaction between CALR and cardiac muscle cells may be related to cardiac pathophysiology. In the nervous system, CALR is associated with neuronal survival and synapse formation, providing insights into research on neurodegenerative diseases.
| Cat.No | ACP02326 | Target Name | CALR |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 18-417aa | Mol Weight | 50.6kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P27797 |
|---|
Uniprot Id
P27797
Target Species
Human
Target Name
CALR
Target Full Name
Calreticulin
Target Function
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy.
Target Subcellular Location
Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Cytolytic granule.
Target Protein Families
Calreticulin family
Target Research Area
Tags & Cell Markers
Target Synonyms
Autoantigen RO; CALR; CALR protein; CALR_HUMAN; Calregulin; Calreticulin; cC1qR; CRP55; CRT; CRTC; Endoplasmic reticulum resident protein 60; Epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; HEL S 99n; RO; Sicca syndrome antigen A (autoantigen Ro; calreticulin); Sicca syndrome antigen A; SSA
Target Background
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.
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