Recombinant Human Cannabinoid receptor 2 (CNR2)

Uniprot Id

P34972

Target Species

Human

Target Name

CNR2

Target Full Name

Cannabinoid receptor 2

Target Function

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spl

Target Research Area

Neuroscience

Target Synonyms

CNR2; CB2A; CB2B; Cannabinoid receptor 2; CB-2; CB2; hCB2; CX5

Target Background

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.