Recombinant Human Carboxypeptidase A6 (CPA6)

Uniprot Id

Q8N4T0

Target Species

Human

Target Name

CPA6

Target Full Name

Carboxypeptidase A6

Target Function

May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine.

Target Involvement

Epilepsy, familial temporal lobe, 5 (ETL5); Febrile seizures, familial, 11 (FEB11)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Protein Families

Peptidase M14 family

Target Tissue Specificity

Expressed in the hippocampus, nucleus raphe, and cortex.

Target Research Area

Signal Transduction

Target Synonyms

CPA6; CPAHCarboxypeptidase A6; EC 3.4.17.-

Target Background

The gene encodes a member of the peptidase M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which catalyzes the release of large hydrophobic C-terminal amino acids. This enzyme has functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Mutations in this gene may be linked to epilepsy and febrile seizures, and a translocation t(6;8)(q26;q13) involving this gene has been associated with Duane retraction syndrome.