Recombinant Human Carboxypeptidase E (CPE), Truncated

Uniprot Id

P16870

Target Species

Human

Target Name

CPE

Target Full Name

Carboxypeptidase E

Target Function

Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.

Target Subcellular Location

[Isoform 1]: Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Secreted.

Target Protein Families

Peptidase M14 family

Target Research Area

Neuroscience

Target Synonyms

Carboxypeptidase E; Carboxypeptidase H; Carboxypeptidase H precursor; CarboxypeptidaseE; CarboxypeptidaseH; CBPE_HUMAN; Cobalt stimulated chromaffin granule carboxypeptidase; CPE; Cph 1; CPH; Enkephalin convertase; Entephalin convertase; Insulin granule associated carboxypeptidase; Prohormone processing carboxypeptidase; Prohormone-processing carboxypeptidase

Target Background

This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes.