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Amino acids 35-155 form the expressed segment for recombinant Human CEACAM3. The calculated molecular weight for this CEACAM3 protein is 29.1 kDa. This CEACAM3 recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of CEACAM3, making it easier to detect and purify the CEACAM3 recombinant protein in the later stages of expression and purification.Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is a protein that takes the spotlight in immunology and infectious disease research. Its primary role lies in the immune system, particularly in the host-pathogen interactions. CEACAM3 is featured in studies exploring the mechanisms of bacterial infections, notably its involvement in the recognition and phagocytosis of bacteria by immune cells, especially neutrophils. In infectious disease research, CEACAM3 works as a receptor for specific pathogens, facilitating their uptake and destruction by immune cells. This makes CEACAM3 a key player in our understanding of how the immune system combats bacterial infections. Additionally, CEACAM3 is implicated in broader areas of immunology, contributing to the understanding of innate immune responses. Its involvement in modulating inflammatory reactions and influencing immune cell behavior broadens its significance in the overall immune system function.
Amino acids 35-155 form the expressed segment for recombinant Human CEACAM3. The calculated molecular weight for this CEACAM3 protein is 29.1 kDa. This CEACAM3 recombinant protein is manufactured in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of CEACAM3, making it easier to detect and purify the CEACAM3 recombinant protein in the later stages of expression and purification.Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is a protein that takes the spotlight in immunology and infectious disease research. Its primary role lies in the immune system, particularly in the host-pathogen interactions. CEACAM3 is featured in studies exploring the mechanisms of bacterial infections, notably its involvement in the recognition and phagocytosis of bacteria by immune cells, especially neutrophils. In infectious disease research, CEACAM3 works as a receptor for specific pathogens, facilitating their uptake and destruction by immune cells. This makes CEACAM3 a key player in our understanding of how the immune system combats bacterial infections. Additionally, CEACAM3 is implicated in broader areas of immunology, contributing to the understanding of innate immune responses. Its involvement in modulating inflammatory reactions and influencing immune cell behavior broadens its significance in the overall immune system function.
| Cat.No | ACP02325 | Target Name | CEACAM3 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 35-155aa | Mol Weight | 29.1kDa |
| Protein Length | Extracellular Domain | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P40198 |
|---|
Uniprot Id
P40198
Target Species
Human
Target Name
CEACAM3
Target Full Name
Cell adhesion molecule CEACAM3
Target Function
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Immunoglobulin superfamily, CEA family
Target Tissue Specificity
CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intesti
Target Research Area
Immunology
Target Synonyms
carcinoembryonic ; Carcinoembryonic antigen CGM1; Carcinoembryonic antigen gene family member 1; carcinoembryonic antigen related cell adhesion molecule 3; Carcinoembryonic antigen-related cell adhesion molecule 3; cd66 d; CD66d; CD66d antigen; CEA; CEACAM 3; CEACAM-3; Ceacam3; CEAM 3; CEAM-3; CEAM3; CEAM3_HUMAN; CGM1; Nonspecific cross reacting antigen; W264; W282
Target Background
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.
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