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| Cat.No | ACP20873 | Target Name | CRTAP |
|---|---|---|---|
| Target Synonyms | CRTAP; CASPCartilage-associated protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 27-401 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75718 |
|---|
Uniprot Id
O75718
Target Species
Human
Target Name
CRTAP
Target Full Name
Cartilage-associated protein
Target Function
Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
Target Involvement
Osteogenesis imperfecta 7 (OI7)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
Leprecan family
Target Tissue Specificity
Found in articular chondrocytes. Expressed in a variety of tissues.
Target Synonyms
CRTAP; CASPCartilage-associated protein
Target Background
The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass.
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