Recombinant Human CASP8-associated protein 2 (CASP8AP2), Truncated

Cat.No	ACP10153	Target Name	CASP8AP2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10153

Target Name

CASP8AP2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UKL3

Background Information

Uniprot Id

Q9UKL3
Target Species

Human
Target Name

CASP8AP2
Target Full Name

CASP8-associated protein 2
Target Function

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Target Subcellular Location

Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation.
Target Synonyms

AA387232; C8AP2_HUMAN; CASP 8 associated protein 2; CASP8 associated protein 2; CASP8-associated protein 2; CASP8AP2; Caspase 8 associated protein 2; CED 4; CED4; D4Ertd659e; FLASH homolog; FLASH homolog RIP 25; FLASH homolog RIP25; FLICE associated huge; FLICE associated huge protein; FLICE-associated huge protein; FLJ11208; KIAA1315; mKIAA1315; OTTMUSP00000005125; RIP 25; RIP25; RP23-69G24.1
Target Background

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.

Recombinant Human CASP8-associated protein 2 (CASP8AP2), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human CASP8-associated protein 2 (CASP8AP2), Truncated Now

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