Recombinant Human Cat eye syndrome critical region protein 2 (CECR2), Truncated

Uniprot Id

Q9BXF3

Target Species

Human

Target Name

CECR2

Target Full Name

Chromatin remodeling regulator CECR2

Target Function

Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The complexes do not have the ability to slide mononucleosomes to the center of a DNA template. The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex. Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes. In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis

Target Tissue Specificity

Highly expressed in skeletal muscle, thymus, placenta and lung. Expressed at lower level in brain, heart, colon, spleen, kidney.

Target Synonyms

CECR2; KIAA1740Cat eye syndrome critical region protein 2