Recombinant Human Cathepsin K (CTSK)

Cat.No	ACP02773	Target Name	CTSK
Target Synonyms	Cathepsin K; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CATK_HUMAN; CTS02; Ctsk; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	115-329aa
Mol Weight	27.5kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02773

Target Name

CTSK

Target Synonyms

Cathepsin K; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CATK_HUMAN; CTS02; Ctsk; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

115-329aa

Mol Weight

27.5kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P43235

Background Information

Uniprot Id

P43235
Target Species

Human
Target Name

CTSK
Target Full Name

Cathepsin K
Target Function

Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
Target Involvement

Pycnodysostosis (PKND)
Target Subcellular Location

Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side.
Target Protein Families

Peptidase C1 family
Target Tissue Specificity

Predominantly expressed in osteoclasts (bones). Expressed in thyroid epithelial cells.
Target Research Area

Signal Transduction
Target Synonyms

Cathepsin K; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CATK_HUMAN; CTS02; Ctsk; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD
Target Background

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Recombinant Human Cathepsin K (CTSK)

Specifications

Immunogen Information

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